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People who might otherwise use modified fasts or bariatric surgery could be candidates for retatrutideand some scientists think certain individuals could see health benefits from greater weight reductions than the drug provides

Due to fluctuations in oestrogen (which plays a key role in preserving muscle and bone mass) levels that we see in line with menopausal changes, (peri)menopausal women are already at risk of muscle loss, and 'losing weight by whatever means could reduce bone and muscle mass further, so it is important that someone taking this medication tries to optimise their diet and physical activity levels as much as possible.' Best exercises to prevent muscle loss on GLP-1s Strength training The most effective protection is resistance and strength training, says Dr Ajaz