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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology ( As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Zha et al., 2024

in International Textbook of Diabetes Mellitus 4th edn Ch 47 (eds DeFronzo, R.A., Ferrannini, E, Alberti, KG, Zimmet, P) (John Wiley & Sons Ltd., 2015)

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The best place to start if you want a hormonal optimization or peptide program is by seeing a physician first