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Preclinical research links it to three main mechanisms: VEGFR2/eNOS angiogenic signaling, Src-caveolin-1-eNOS nitric oxide modulation, and FAK/paxillin cell-migration signaling

in the 2021 survey from GI Society, 91% of respondents reported comorbidities such as arthritis (51%), hypertension (33%), sleep apnea (30%), gastroesophageal reflux disease (29%), irritable bowel syndrome (29%), high cholesterol (25%), and diabetes (24%)