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These included: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent, occurring more frequently and with greater severity at higher doses

SEMA Partially Mitigates STZ-Induced Hyperglycemia and HbA1C Increase Without Influencing Body Weight Four weeks after the STZ injection, STZ-treated rats exhibited a significant elevation in blood glucose levels (Figure 3a, red, blue, and green curves) relative to the sham group (Figure 3a, black curve)

Endoplasmic reticulum oxidoreductin provides resilience against reductive stress and hypoxic conditions by mediating luminal redox dynamics

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