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Gastrointestinal Fluid Loss The most common GLP-1 side effects are gastrointestinal: Nausea: 44% of Wegovy users, 56% of Zepbound users Vomiting: Increases relative risk 2.90-2.95x vs placebo Diarrhea: Common across all GLP-1 medications Each episode of vomiting or diarrhea depletes 100-500mg of sodium plus potassium, magnesium, and calcium

More of those on the 3 mg dose lost 5% or more of their total body weight than those on the placebo

Many patients find that nausea feels less bothersome when they're not rushing or engaging in strenuous activity immediately after injection