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To assess the translational efficiency of the PRKAA1 5UTR in shCtrl cells, FLuc activity was divided by RLuc activity in the 5UTR reporter group and normalized to that of the empty reporter group to calculate relative luciferase activity

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Early studies presented at ASCO in 2026 and research at the San Antonio Breast Cancer Symposium in 2025 suggest the answer may be promising, but the science is still developing