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Although many studies have reported changes in DNA methylation or histone states alongside depressive or addiction-related phenotypes, it is still unclear whether these changes exert causal influence or simply arise as consequences of the disease process
doi: 10.1186/s13075-016-1161-4 105 EkwallA-KHWhitakerJWHammakerDBugbeeWDWangWFiresteinGS
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Interestingly, another study confirmed that the SIRT7 can aggravate kidney damage in I/R-induced AKI, and the knockout of SIRT7 protects mice from I/R-induced AKI through inhibiting the activation of NF-B pathway and reducing the expression of pro-inflammatory factors
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