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Key findings from the Phase 2 trial included: Dose-dependent weight loss , with greater reductions observed at higher doses Significant improvements in waist circumference , blood pressure , and lipid profiles Reductions in fasting glucose and insulin resistance markers, though the clinical significance of these findings in people with type 2 diabetes requires further investigation Weight loss appeared to continue throughout the 48-week period without a clear plateau at the highest doses Whilst these results are encouraging, it is important to contextualise them appropriately

BMJ 340:c869

Jimnez-Reina L, Caete R, de la Torre MJ, Bernal G

GIP (glucose-dependent insulinotropic polypeptide) further enhances insulin sensitivity and may directly influence fat metabolism in adipose tissue