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The medication influences key hormonal and neural pathways involved in appetite regulation, satiety, and energy expenditure

Four other patients started the study but withdrew and returned to the standard weekly dosing schedule after gaining some weight before their first three-month follow-up visit for the trial

Recent studies suggest that treatment with semaglutide (GLP-1RA) in combination with firsocostat (ACC-a inhibitor) and/or cilofexor (nonsteroidal FXR agonist) can further improve hepatic steatosis and thus NAFLD compared with semaglutide alone in exploratory efficacy analyses [113]

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