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Contraindications and Side Effects Mounjaro (tirzepatide) medications should not be used in individuals with: Medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) Known hypersensitivity to tirzepatide or any components in the formulation According to clinical data, the most common side effects of Mounjaro include: Nausea Diarrhea Decreased appetite Vomiting Constipation Indigestion Abdominal discomfort Providers should discuss the risk of thyroid C-cell tumors with patients, although this remains a rare concern based on preclinical models