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It influences autonomic nervous system activity, promotes endogenous opioid release, alters cytokine profiles, and regulates key metabolic signaling pathways, including AMP-activated protein kinase (AMPK), phosphoinositide 3-kinase/Akt (PI3K/Akt), and sirtuin 1 (SIRT1) (28, 29)

Consistent with this expectation, Argyrakopoulou et al reported that in a cohort of obese individuals treated with liraglutide, the dominant change was a reduction in fat mass, accompanied by only a minimal decline in lean mass