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or severe nausea, vomiting, or diarrhea leading to dehydration

It continues to bind to GLP-1 receptors, slow gastric emptying, and influence appetite signaling in the brain at the same dose

Other, less common side effects of oral semaglutide include: Bloating Upset stomach Belching Flatulence Gastritis (stomach inflammation) While rare, oral semaglutide can also cause serious side effects, including: Acute pancreatitis Diabetic retinopathy complications (diabetes-related vision changes) Hypoglycemia (low blood sugar) when used with insulin and similar medications Kidney or gallbladder issues Severe gastrointestinal reactions Severe allergic reactions Pulmonary aspiration during general anesthesia or deep sedation In animal studies, semaglutide caused thyroid tumors, but its unclear if this occurs in humans

A poorly mixed peptide is either ineffective or potentially unsafe