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SELECT was a randomized, placebo-controlled, phase 3 trial evaluating whether semaglutide as an adjunct to standard of care was superior to placebo in decreasing MACE risk in 17,604 non-diabetic patients with obesity or overweight and cardiovascular disease (CVD)

In the field of MAFLD, SIRT1 has been identified as a highly promising target, with various activators demonstrating potential in improving lipid metabolism, suppressing inflammation, and mitigating fibrosis in studies