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Description

Both involve altered pain processing, but allodynia involves a fundamentally inappropriate pain response to non-painful input, while hyperalgesia involves an exaggerated response to actually painful input

As such, patients considering this combination therapy should be closely monitored by their healthcare providers to manage and mitigate these risks effectively

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Additionally, some antimalarial drugs, blood pressure medications (beta-blockers), and even certain herbal supplements can interact, necessitating careful monitoring