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The presence of endotoxins in the bloodstream can lead to various adverse effects, including sepsis, systemic inflammatory response syndrome (SIRS), and the worsening of already existing diseases like liver dysfunction, renal failure, and acute respiratory distress syndrome (ARDS)

Repeated compression of the dosing interval increases your average drug exposure beyond what was prescribed, elevates side effect risk, and disrupts the steady-state pharmacokinetics that your body has adapted to

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Gastrointestinal side effects such as nausea, vomiting, and constipation are most common during dose escalation