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Absolute Contraindications (You Cannot Use Tirzepatide If:) According to the safety information, you should NOT use compounded tirzepatide if: Personal or Family History of Medullary Thyroid Carcinoma (MTC): You have ever had MTC (a type of thyroid cancer) Any family member has ever had MTC This is an absolute contraindication due to the risk of thyroid C-cell tumors observed in animal studies Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2): You have been diagnosed with MEN 2 (an inherited endocrine disorder) This significantly increases MTC risk Known Allergic Reaction to Tirzepatide: If you've taken tirzepatide before and had a severe allergic reaction Relative Contraindications and Caution Situations The following situations require careful evaluation by your provider and may prevent you from qualifying: History of Pancreatitis: Tirzepatide has not been studied in patients with a history of pancreatitis GLP-1 medications are associated with increased pancreatitis risk Providers may decline to prescribe if you have a history of pancreatitis Severe Gastrointestinal Disease: If you have gastroparesis (delayed stomach emptying) Severe inflammatory bowel disease History of bowel obstruction Tirzepatide slows gastric emptying and could worsen these conditions Diabetic Retinopathy: Rapid glucose improvement can temporarily worsen diabetic retinopathy If you have diabetic eye disease, close monitoring is required Kidney Disease: Dehydration from GI side effects can worsen kidney function Providers evaluate kidney function before prescribing Pregnancy and Breastfeeding: Pregnant: Compounded tirzepatide should NOT be used during pregnancy