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Takeaway: Semaglutide may cause vision changes due to blood sugar swings, diabetic retinopathy, or eventually NAION

doi: 10.1093/jn/nxz034 54 BikleDD

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Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear