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The study is described as a first-of-its-kind global clinical trial designed to evaluate whether combining a proven multidomain lifestyle intervention with a metabolism-targeting drug, such as a GLP-1 agonist, can further reduce the risk of cognitive decline, mild cognitive impairment (MCI), and dementia in at-risk older adults

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Prescribing unlicensed medicines is legally permissible in the UK under specific circumstances, but clinicians bear additional responsibility for justifying such use and ensuring informed consent