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Description

Additional fibrosis-associated genes activated by TGF- in OA include ECM-encoding genes COL1A1, COL3A1, COL5A1, FN1 , and key enzymes important for collagen synthesis such PLOD2 , prolyl 4-hydroxylase subunit alpha 3 (P4HA3 ), and lysyl oxidases ( LOXs ) (91, 106, 119)

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