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Although an HbA1c 6.5% may be used for diagnosis, it should not be the sole screening tool during this period ( 6 Prevention and management strategies 6.1 Modification of immunosuppression Given that immunosuppressants account for up to 74% of the attributable risk for PTDM, modifying the immunosuppressive regimen is a primary strategy ( Corticosteroids: Early and rapid tapering of corticosteroids to a low maintenance dose (e.g., 5 mg/day prednisone) or the use of steroid-free regimens can significantly reduce the risk of PTDM ( CNIs: Minimizing tacrolimus exposure by maintaining target trough levels below 10 ng/mL effectively reduces the incidence of PTDM (116)

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Furman, B

We suppose the change is because the initial doses are enough to keep B12 levels within the desired range

Consistent absorption: SubQ absorption is generally more predictable than IM, as its less affected by blood flow variations from physical activity