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Importantly, the authors of this work similarly did not interpret their findings related to cerebrovascular resistance as negative adaptations to RT, but instead consider the increase to be a protective response to reduce the effects of increased mean arterial pressure on the cerebral circulation - where hyperperfusion can damage the microvasculature (Thomas et al., 2021)

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[DOI] [PubMed] [Google Scholar] Djordjevic, N

Similarly to the dueling extracellular GABA uptake vs intrinsic Put-GABA synthesis models of the source for striatal GABA released from DA neurons, these two proposed mechanisms of SCN astrocyte regulation of GABA neurotransmission are not mutually exclusive