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They have alterations in their gut microbiome and metabolic hormones

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This pathway is activated under times of oxidative stress to enhance the expression of a multitude of antioxidant and phase II liver detoxification enzymes that restore homeostasis to the ox/redox cycles in the body (41, 42, 43)

In fact, ALCAR concentrations slowly decline as cognitive impairment progresses , being 22% lower than normal in those with subjective memory complaints, 28% lower in those with mild cognitive impairment, and 36% lower in Alzheimers patients [14]