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The concern stems from its activation of the VEGFR2 pathway and FAK-paxillin signaling, which drive angiogenesis and are dysregulated in 50% of human cancers (ovarian cancer, melanoma, and colon adenocarcinoma)

Aucatzyls edge appears to be its safety, with a low incidence of cytokine release syndrome and grade 3 toxicities, as well as no grade 4 or 5 adverse events