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For example, other studies show similar effects on: plasma measurement of DNA [40, 41], thiols [42], and creatinine [43]

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A meta-analysis of 16 clinical trials (N=6,276) did not find a significant effect of vitamin supplementation on depressive symptoms.38 However, a review of five clinical trials (N=6,507) by da Silva and colleagues found that supplementation with folic acid, vitamin B6, and vitamin B12 was effective in preventing depression in patients recovering from stroke.39 Supplementation with folic acid, vitamin B6, and vitamin B12 may improve symptoms of depression and bipolar disorder among patients with these disorders by increasing the absorption and utilization of mood-stabilizing medications.35 Hyperhomocysteinemia is also associated with an increased risk of schizophrenia