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The FDA-approved criteria require a BMI of 30 or greater (obesity), or a BMI of 27 or greater with at least one weight-related comorbidity such as type 2 diabetes, high blood pressure, high cholesterol, obstructive sleep apnea, or cardiovascular disease

Standard titration is the FDA-approved process of starting at a low dose (typically 2.5 mg) and increasing every four weeks until a maintenance dose is reached to achieve the significant weight loss seen in clinical trials

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