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Alpha-lipoic acid may interact with certain medications, and patients should inform their healthcare provider of all drugs and supplements they are taking to avoid adverse interactions

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Overweight and obesity management (NG246) Appendix P: NICE guideline CG43 [PDF]

Reported effects are mild and transient: Localized irritation or redness at injection site, Mild fatigue or transient headache during initial days, Rare gastrointestinal upset (nausea, stomach discomfort)