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At specific time points (4- and 8-weeks post-infection), three mice from each group were euthanized, and approximately 0.7 ml of blood was collected by cardiac puncture

In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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Aggregated -synuclein fibrils, dopamine-derived quinones, and mitochondrial DAMPs, including cardiolipin and mtDNA, are strong inducers of microglial NLRP3 inflammasome activation in PD