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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

When compared with injectable GLP-1 agonists, orforglipron's discontinuation rates are broadly similar

The definition of injection site reactions in clinical trials typically includes pain, erythema, pruritus, and other local symptoms that patients report to investigators

Administration: It is important to use the Mounjaro injection on the same day each week and rotate injection sites (abdomen, thigh, or upper arm) to minimise local irritation