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Although they each have their roles, vitamin B12 works closely with another B vitamin, folate, for the proper function of the nervous system, production of healthy red blood cells, and in S-adenosylmethionine (SAMe), a compound that supports mood and immune function 1

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In vitro , GSH-deficient hepatocytes show upregulated mRNA levels of DNA methyltransferase, Tet2, and Tet3, along with increased Dnmt activity (5-mC) and global DNA methylation levels