Headache occurs in 6-8% of patients, while dizziness and fatigue are less common
Dial your prescribed dose (typically starting at 0.25 mg for the first 4 weeks)
Foods to minimize or avoid include: Carbonated beverages, which introduce additional gas High-fiber foods initially (beans, cruciferous vegetables, whole grains), though fiber remains important long-term Artificial sweeteners, particularly sugar alcohols (sorbitol, xylitol), which can ferment in the gut Dairy products if lactose intolerance is present or suspected Fried or greasy foods that slow digestion Hydration remains essential, but patients should sip water throughout the day rather than consuming large volumes with meals, which can increase stomach distension
A recurring theme across non-incretin metabolic peptides is that early development efforts were constrained by pleiotropy, cardiovascular effects, or incomplete receptor characterization rather than by lack of metabolic relevance