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Theyre regulated by the Drug Quality and Security Act (DQSA), which requires compounders to meet certain conditions

For many, this symptom is most common in the first few weeks of treatment or immediately following a dose increase

Moreover, gut microbial alterations, such as reduced Akkermansia muciniphila in severe periodontitis, can be restored via periodontal therapy or FMT, improving gut barrier function and ameliorating periodontal inflammation (Zhang et al., 2025)

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