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"The lower list price is intended to connect more people with our innovative medicines, specifically those whose out-of-pocket costs are linked to list price, such as individuals with high-deductible health plans or co-insurance benefit designs, said Millar in the statement
This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) ( In addition to the NF-B pathway, the mitogen-activated protein kinase (MAPK) signaling cascade is also an important regulator of inflammatory responses in CNS microglia
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