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Patients turn the dose selector until the desired dose (0.25 mg, 0.5 mg, 1 mg, or 2 mg) aligns with the dose pointer in the window

The fact that the double-cysteine mutations only partially abolish the physiological function may imply that not all the expressed mutants have an intact disulfide bridge and that the observed conformation is only one possible inactive state on the cell surface, as supported by the EM data and MD simulations below

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doi: 10.2337/diab.46.11.1893 150 JinFHuHXuMZhanSWangYZhangHet al