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Testosterone supports lean mass maintenance, and low levels predispose toward muscle loss during weight loss

For example, in one study participants who had depression and low vitamin B12 levels who were given B12 and antidepressants showed a greater improvement in symptoms than those who only received antidepressants

While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

Inadequate PT adherence Premature return to high-impact activities Comorbidities (diabetes, obesity, autoimmune conditions) Ongoing smoking or alcohol use Inadvertent NSAID use during recovery Injury severity beyond PRP capability When Should You Follow Up With Your Provider