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GLP-1s often lead to 3050 pounds of weight loss, while surgery can result in far greater total body weight reduction, particularly in those with a BMI over 40 or severe obesity-related health issues

This effect is mediated through vagal nerve pathways and direct GLP-1 receptor activation in the gastrointestinal tract

One could reasonably argue that Pendulums record of research backing and clinical trials (not to mention the ongoing series of the latter) provides peace of mind thats reflected in the price tags

"These results are not surprising and are consistent with other research evaluating GLP-1 medications and observed weight loss," says Metzgar