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Intriguingly, a significant increase in total and selenium-dependent GPx ratios was observed ( P = 0.0099 and P = 0.0096, respectively) (Figures 6D and E), indicating an adaptive upregulation to mitigate oxidative damage, while the non-selenium-dependent GPx ratio remained stable (Figure 6F)

Failure to clear senescent cells also lead to a pro-tumorigenic microenvironment characterized by chronic inflammation because of the SASP 12,25

MCAS is a complex, underdiagnosed condition in which mast cellskey players in the immune systembecome hyperactive and release inflammatory mediators inappropriately , even without a traditional allergic trigger