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Repeatedly applying patches to the same location can cause contact dermatitis, skin sensitization, or localized tissue changes that impair drug absorption
N Jelovac , P Sikiric, R Rucman, M Petek, D Perovic, A Marovic, T Anic, S Seiwerth, S Mise, B Pigac, B Duplancie, B Turkovic, G Dodig, I Prkacin, D Stancic-Rokotov, I Zoricic, G Aralica, B Sebecic, T Ziger, Z Slobodnjak, The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam
Alzheimers Drug Discovery Foundation