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Complementary strategies include convection-enhanced delivery (CED) systems that enhance parenchymal drug distribution and chemical modifications (e.g., lipid group conjugation) to improve drug lipophilicity for BBB transit [109, 110]
doi: 10.1186/s40168-019-0712-8 52 MoralesC.RojasG.RebolledoC.Rojas-HerreraM.Arias-CarrascoR.Cuadros-OrellanaS.et al
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Cancer Cell 37, 289307.e289
The warnings affect the thiazolidinedione class of antidiabetic drugs, which includes rosiglitazone (Avandia), pioglitazone (Actos), rosiglitazone and glimepiride (Avandaryl), rosiglitazone and metformin (Avandamet), and pioglitazone and glimepiride (Duetact)
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