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In many cases, peptides were evaluated in isolation, at supraphysiologic doses, and without consideration of compensatory physiological mechanisms

Long-term effects unknown : While the clinical trials look good, the long-term safety and efficacy of tirzepatide, especially for weight loss, is still being studied

Patients in whom heart failure (HF) or chronic kidney disease (CKD) is prevalent, should receive a treatment intensification with an SGLT-2 inhibitor with the respective evidence from clinical studies due to the respective data (7072)

This therapy continues to be investigated and has attracted attention for its potential efficacy and safety