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Making it a research tool for studying melanocortin pathway contributions to appetite regulation and energy homeostasis

Neurobiol Aging 27:12501257 Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H (2001) Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling

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and physical changes like insomnia, difficulty concentrating, irritability, fatigue, and increased blood pressure