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In liver disease, S100A9 is released during liver necrosis, which binds to NLRP3 on hematopoietic stem cells and myofibroblasts, mediating an increase in the expression of TNF and IL-17 [197], which triggers an inflammatory response and promotes the synthesis of extracellular collagen, ultimately leading to liver fibrosis [198]
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Specifically, the number of macrophages and dendritic cells was decreased in the lung lavage fluid of mice exposed to cigarette smoke and provided the tachykinin receptor antagonist AVE5883
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