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Whilst berberine may offer modest metabolic benefits through various mechanisms, it should not be viewed as a replacement for evidence-based medical treatments or lifestyle modifications that form the cornerstone of metabolic disease management

CONCLUSION The potential of these new therapies to effectively treat obesity and T2DM and radically reduce their complications pose a major challenge to the health authorities who will need to decide how these new possibilities should be implemented to the benefit of the people at risk

There is no organ system that is not affected by this internal metabolic environment. GLP-1-based drugs are very effective at helping people reduce their calorie intake, which could directly affect insulin sensitivity and glucose metabolism, says Ard