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Adherence is crucial for treatment success, so addressing barriers early ensures long-term commitment to the treatment plan

The ADA guidelines have historically mentioned the benefits of these agents in the use of REDUCED ejection fraction heart failure (HFrEF)

LEADER [29] and SUSTAIN-6 [30] reported a prespecified renal composite of new onset or persistent macroalbuminuria, persistent doubling of serum creatinine and eGFR 45 mL/min/1.73 m 2 , need for renal replacement therapy (RRT), and renal death

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