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When patients discontinue semaglutide, weight regain occurs more slowly and less completely than with phentermine, because metabolic improvements partially persist

Concomitant use with alcohol or CNS depressant drugs (e.g., barbiturates, benzodiazepines, hypnotic agents) may potentiate CNS depression or other centrally mediated effects of these agents (e.g., dizziness, adverse cognitive reactions, drowsiness, lightheadedness, impaired coordination, somnolence)

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Visual changes often signal heat damage: cloudiness, discoloration, or visible particles in the solution indicate the medication has been compromised