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This signaling cascade enhances transcription of melanogenic enzymes, promoting melanin synthesis within melanocytes

OR Your starting BMI was 30 or higher and you had at least one of the following: Heart failure with preserved ejection fraction Uncontrolled high blood pressure despite treatment with two blood pressure medications Chronic kidney disease stage 3a or higher OR Your starting BMI was 27 or higher and you had at least one of the following: Prediabetes Previous heart attack Previous stroke Symptomatic peripheral artery disease Skippack Pharmacy does not make the final eligibility decision

The primary outcome was 30-day readmission, and secondary outcomes were documented dehiscence, infection, hematoma, and bleeding within 180 days after surgery

10.1016/j.cell.2006.02.008 26 CsiszrJ.HorvthE.VryZ.Gall.BelaK.BrunnerS.et al