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Nat Chem Biol 22 , 446458 (2026)

Those with chronic inflammation, sun damage, hyperpigmentation, or acne scarring

Patients with pre-existing gastroparesis or severe gastric motility disorders should consult their physician before starting semaglutide, since further slowing of stomach emptying could worsen symptoms

One of the most well-accepted treatments is the glutathione injection, which helps in skin whitening or lightening by targeting the root causes of darkening and uneven skin tones