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Rocio Salas-Whalen, a physician specializing in endocrinology, obesity, and metabolic health, and the author of Weightless: A Doctor's Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve

Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids

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