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Menstrual Side Effects: What to Expect and When to Seek Help Common menstrual changes during semaglutide therapy include irregular cycle length (shorter or longer intervals), lighter or heavier bleeding, missed periods, and changes in premenstrual symptoms like cramping or breast tenderness

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Where things fall short is clinical oversight: Provider check-ins take place only every six months, and to get clarity on how often patients actually interact with a provider, I had to reach out myself