glp 1 and ddp4 combination The mechanism of action of GLP-1 analogs (DPP-4 resistant). DPP-4 = Frontiers | Physiology and Pharmacology

Brain Research, 1117(1), 54-60

Historic result from SURMOUNT-3: When tirzepatide was combined with intensive lifestyle intervention, patients achieved an average of 26.6% body weight loss the highest average weight loss ever recorded in a controlled clinical drug trial

So a bunch of different scientists started testing it in Petri dishes and in animals, and it turns out GLP-1 increases insulin release and lowers blood sugar and slows the rate the stomach empties out and makes people feel more full and eat less, exactly the things that could help treat type two diabetes

Proteomic analysis identified 156 DEPs, with glutathione metabolism being the most severely disrupted pathway