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Animal Studies Administration of IGF-1 LR3 to rodents produces dose-dependent increases in body weight and lean body mass, with the weight gain being primarily accounted for by increases in skeletal muscle mass rather than fat accumulation

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2.1.1 Monoamine transporter disruption and neurotransmitter release METH disrupts the reuptake and enhances the release of dopamine, serotonin, and norepinephrine, significantly increasing their extracellular concentrations